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A Novel Therapy Tool in the Nervous System: Exosomes
Zhou Wenshu, Du Xuewei, Wang Ruofeng, Li Tianqing*
Kunming University of Science and Technology, Primates Translational Medicine Research Institute, Kunming 650000, China
Abstract: Exosomes are small extracellular membrane-based vesicles with a variety of cargoes that are involved in numerous physiological and pathological processes in the nervous system. Many researchers have been shown that exosomes play an active role in intercellular communication within the nervous system. At the same times， exosomes play a vital role in the treatment of nervous system diseases， they may be as biomarkers for diagnosis of diseases and molecule-delivery vehicles. The underlying mechanism of interest involves the selective transport of cellular cargo. Thus， exosomes are expected to be an important tool in the treatment of neurodegenerative disease. However， in this review， we first illustrated the basis characteristic of its formation， storage， isolation of method. Second， we discussed the role of exosomes derived-MSCs in the diagnosis and treatment of neurodegenerative diseases. Third， we discussed that exosomes would face the challenges that as a novel treat tool in the nervous system disease. This article illustrates an updated review of this fast-progressing field of exosomes and their role in the nervous system diseases， particularly focusing on their therapeutic applications.
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