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The Molecular Mechanism and Prospect for Clinical Application of Lingo-1 Inhibiting the Remyelination
Yin Wen1, Li Hongli2*
1Squadron 13 of School of Basic Medicine, Army Medical University, Chongqing 400038, China; 2Department of Histology and Embryology, Army Medical University, Chongqing 400038, China
Abstract: Leucine-rich repeat and Ig domain containing， Nogo receptor-interacting protein 1 (Lingo-1) is a transmembrane protein selectively expressed in central nervous system. Recent studies on remyelination have observed high expression of Lingo-1 after central nervous system damage， inhibiting remyelination of damaged neurons by inhibiting differentiation of oligodendrocyte progenitor cells (OPCs) and reducing survival rate of neurons. Current researches indicate that Lingo-1 can be used as an important new target to promote nerve repair after damage. This review focuses on the functionary mechanism of Lingo-1 in the remyelination of central nervous system.
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