Skeletal Muscle Derived-Exosome Promotes Proliferation and Inhibits Differentiation of Muscle Stem Cells

Abstract: Adult skeletal muscle stem cells， also known as satellite cells， are located between the plasma membrane of a muscle fiber and the basal lamina. As an immediate niche， myofiber regulates satellite cell function by secreting various cytokines. Interestingly， recent studies indicate exosomes secreted from skeletal muscle could modify the functions of other tissues as an endocrine component. However， whether muscle-derived exosomes as a paracrine signaling regulate satellite cell function remains elusive. Herein， we demonstrate skeletal musclederived exosomes significantly promote proliferation and inhibit differentiation of satellite cells. Thus， the present study provides experimental evidence to support muscle exosome-mediated niche regulation on satellite cell functions.

CSTR: 32200.14.cjcb.2018.07.0013