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Safeguarding Genomic Stability in Pluripotent Stem Cells
Zhang Weidao, Zheng Ping*
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
Abstract: Pluripotent stem cells (PSCs) hold great promise for cell-based regenerative medicine. However， genomic instability and tumorigenicity hamper their full applications. Understanding the mechanisms that regulate their genome stability is critical to address this issue. Due to the specific functional purpose， PSCs possess high competence to safeguard genomic stability by employing specific strategies. In this review， we summarized the current progress in understanding the mechanisms that the PSCs utilize to cope with DNA replication stress， to repair DNA damage， and to determine the cell fates after unrepairable damage.
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