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Regulation of Exosomes on Bone Remodelling
Guo Jianmin1, Zou Jun2, Wang Miao1, Chen Xi3*
1School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China; 2Development and Planning Department, Shanghai University of Sport, Shanghai 200438 China; 3School of Sports Science, Wenzhou Medical University, Wenzhou 325035 China
Abstract: Exosomes are small sized vesicles released into the extracellular space， which play important roles in the regulation of cell-to-cell communication through delivery of bioactive molceules such as lipids， mRNA， microRNA and proteins. Exosomes transfer their contents by direct fusion with the membrane of recipient cells or by endocytosis. It was found that the influence of exosomes on the cells might due to pathological conditions or at different stages of differentiation. Thus， exosomes can be the biomarkers for diagnosesor assessing cell differentiation. Previous studies found that exosomes derived from different cells played a key role inregulation of bone remodelling through affecting bone formation and bone resorption by regulate the proliferation， differentiation and apoptosis of various cells in the bones. It also have been showed that exosomes play essential roles in the dieases developing of osteoporosis， femoral head necrosis， fractures， skull defects， cartilage defects.
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