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Research Status of Long Non-Coding RNAs (LncRNAs) in Human Breast Cancer
Bi Mingyu, Dai Wenzhu, Hu Fei, Liu Ning, Zheng Ling, He Jixinag, Tang Wenru, Sheng Miaomiao*
Laboratory of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Kunming 650500, China
Abstract: The discovery of long non-coding RNAs (LncRNAs) have changed our understanding of transcription and post-transcriptional regulation. With the development of new technologies such as high-throughput sequencing， LncRNAs have become the focus of cancer research. The biological functions of LncRNAs have been gradually understood. Several studies have shown that LncRNAs can directly or indirectly regulate gene expression and cell biological functions. The tissue-specific expression features of lncRNAs can be used to distinguish between normal and breast cancer tissues， as well as different stages of tumor development， suggesting that LncRNAs are expected to provide new molecular targets for early diagnosis， therapeutic efficacy prediction， and treatment of breast cancer. Therefore， this article reviews the function of LncRNAs and the research status in breast cancer.
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