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Recent Advances of Research on Eukaryotic Translation Initiation Factor 5A2 in Tumors
Yu Hanxiao, Xie Yuqiong, Cao Jiang*
Clinical Research Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Abstract: Eukaryotic translation initiation factor 5A2 is a protein which plays roles in translation initiation and elongation processes in eukaryotic cells. It is one isoform of eIF5A. The aberrant overexpression of eIF5A2 in many types of tumor cells is associated with tumorigenesis and progression. Hypusine， a unique amino acid residue component of eIF5A， may become a potential target for antitumor therapy and bring new ideas in the clinical treatment.
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