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Application Progress of High Content Screening in Prediction of Drug-Induced Hepatotoxicity
Jiao Yuhan, Feng Yang, Li Haizhou*
College of Life Science and Technology, Kunming University of Science and Technology, Kunming 650000, China
Abstract: Many listed new drugs was warned， withdrawn or restricted due to liver toxicity problems. Therefore， to evaluate the hepatotoxicity and ensure the safety of drugs in clinical use has become an important aspect in the process of new drug research and development. High content screening technology is a relatively new technology developed in recent years， which can be used for multi-parameter， multi-target and high throughput detection and analysis of drug hepatotoxicity in vitro. Based on toxicity pathways of high content screening is the important idea of liver toxicity prediction. This article mainly introduces the application progress of drug-induced essential liver injury and specific liver injury， which based on toxicity pathways of HCS (including steatosis， phospholipids， cholestasis， genetic material damage， etc).
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