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Adult Stem Cell Niche and Lung Repair
Xue-Mei Shi, Hui-Lan Zhang*, Sheng-Dao Xiong
Key Institute of Respiratory Disease of Ministry of Public Health, Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Abstract: Lung is an opening complex organ， of which the epithelia is easily injuried by pathogenic microorganism and atmospheric pollutants resulting from continuously exposure to them. So the topic about its repairment in structure and function is still a hot spot in research. Adult stem cells have multi-directional differentiation potency， which can differentiated into different cells within different niche. Different region of lung has different stem cells， which have proliferation and transdifferentiation under some conditioned situation. So the repairment of lung in structure and function can be achieved by these stem cells in different level and their own repairing method. Now some aspects of these stem cells about its source， its effect and mechanism in lung repair are still unclear， so this article reviews some related progresses in order to provide a new recognition of lung repair.
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