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Roles of GDNF in the Proliferation and Differentiation of Spermatogonial Stem Cells
Shan-Shan Liu, Shu-Feng Li, Dan-Dan Li, Dan-Yang, Yun-Qin Yan*
Histology and Embryology Unit, College of Biological Sciences, Northeast Agriculture University, Harbin 150030, China
Abstract: The roles of glial cell line-derived neurotrophic factor (GDNF) and its receptors during the processes of proliferation and differentiation in spermatogonial stem cells were reviewed in this article. It has been proved that GDNF gets involved in the activation of undifferentiated spermatogonia growth， the regulation of the micro-environment of spermatogonial stem cell self-renewal/differentiation and the participation in the first step of differentiation. According to these researches， GDNF is an important nutritional factor in the survival of spermatogonial stem cells.
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