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The Fate of Cells: Pharmacokinetics of MSC
Han Li1,3, Hui Lijian2,3, Pan Guoyu1,3*
1Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China; 2Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai 200031, China; 3University of Chinese Academy of Sciences, Beijing 100049, China
Abstract: Recently， cellular drugs have become one of the hottest areas in drug development. Cellular drugs are quite different from the traditional small molecules and macromolecular drugs， because of their proliferation and chemotactic abilities. With the help of pharmacokinetic theories， it would be feasible to describe and predict the fate of cell drugs， characterize their distribution， metabolism， and excretion in the body. That will improve the clinical efficacy and safety of the cellular drugs， reducethe risk of drug-drug interactions. In this paper， we take mesenchymal stem cell (MSC) as an example， trying to clarify the relationship between the pharmacokinetics and the efficacy/toxicity (PK/PD/TD) of cell drugs according to published literatures.
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