Home > Browse Issues > Vol.29 No.6
Glia and Pathological Pain
Shan Sun1,2, Jun-Peng Gao1, Ning Lü2*, Ding-Fang Cai1*
1Integrative Medicine Department, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; 2Institue of Neurobiology, Fudan University, Shanghai, 200032, China
Abstract: In the central nervous system， glial cells play an important role in the development and maintenance of central sensitization. Glial cells express many receptors of neurotransmitters and cytokines. Robust glial activation has been observed on the lumbar spinal cord in various rodent models of chronic pain. The degree and time course of glial activation are correlated with pain facilitation. Activated spinal glia release a variety of algesic substances， such as pro-inflammatory cytokines， which enhance pain transmission. Glial cells will be targeted in order to kill pathological pain.
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