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Research Progress on Neural Stem Cell Activation
Gao Xuehu, Luo Yuping*
School of Life Sciences, Nanchang University, Nanchang 330031, China
Abstract: Neural stem cells (NSCs) are stem cells that with the ability of self-renewal and multiple differentiation potential. Under certain circumstances， NSCs are able to differentiate into neurons， astrocytes and oligodendrocytes， thereby participating in the neurogenesis and injury repair. Normally， adult NSCs are mostly quiescent state. Recent research showed that under pathological conditions， quiescent NSCs could be activated， proliferated， migrated and differentiated into new neurons and reconstruct neural circuit in damaged sites. This review summarized the characteristics of quiescent and active NSCs and the cellular and molecular mechanisms underlying the activation of quiescent NSCs.
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