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The Effects of Chemokine SDF-1 on ADSCs Differentiation into VECs
Lai Defang, Wang Qing, Liu Dongjun*
State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, College of Life Sciences of Inner Mongolia University, Hohhot 010070, China
Abstract: Recently years， many researches demonstrate that tissues ischemia， renal insufficiency， cancer， heart and cerebral vessels diseases etc. are tightly related with vascular lesion. Therefore， reduce the vascular lesion and recover their normal function have been accepted as the hot topic of cytology. Adipose derived stem cells (ADSCs) derived from adipose tissues could be efficiently induced to vessel endothelial cells (VECs) in vitro， and more significant factors (chemokine) have been found during this process， such as VEGF， bFGF， IGF-1， SDF-1 (CXCL12) etc.. Angiopoiesis results are affected by chemokine content and induction period. Furthermore， chemokine secreted by ADSCs also can promote the rates of angiopoiesis in vitro. The effects of the chemokine SDF-1 on angiopoiesis are summarized in this article in resent years. This article provides a theoretical references for the relative animal models establishment and human diseases research.
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