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Advances of the Contradictory Relationship between Plasma Adiponectin Level and Type 2 Diabetes Mellitus and Cardiovascular Disease
Zhao Huimin1,2,3, Lei Zili1,2, Guo Jiao1,2,3*
1Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China; 2Traditional Chinese Medicine Academy of Guangdong Pharmaceutical University, Guangzhou 510006, China; 3The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510006, China
Abstract: As a cytokine produced and secreted by the adipocyte， adiponectin has been confirmed with sensitization， anti-inflammatory， antioxidant， anti-atherosclerosis and anti-apoptosis in the cell and animal experiments. However， in the epidemiologic and genomic research in large population， these beneficial effects of adiponectin are not able to compeletely reproduction. This review aims to induce and summarize the contradictory relationship of adiponectin and type 2 diabetes mellitus， cardiovascular disease， and then analysis of the cause of this contradictory relationship， so that to provide a scientific basis for the further study of adiponectin in type 2 diabetes mellitues and cardiovascular disease.
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