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The Effect of lncRNAs on Osteogenesis Differentiation of Stem Cells
Zhang Miao1, Li Hui1, Zhou Xuchang1, Zou Jun1,2*
1School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China; 2Development and Planning Office, Shanghai University of Sport, Shanghai 200438, China
Abstract: With the development of science and technology， the studies on bone diseases research have gradually penetrated into molecular mechanism. In recent years， stem cells differentiation and self-renewal ability provides a new perspective for treatment of a variety of bone diseases. Long non-coding RNAs (lncRNAs) are a class of RNAs molecules with a length of more than 200 nt. They are not directly involved in the protein coding. They are involved in chromatin remodeling， DNA methylation and histone modification， and serve as precursors of miRNA to regulate cell proliferation and differentiation. Latest investigation shows that lncRNAs play a key role in maintaining the dynamic balance of bone metabolism， and is involved in the process of stem cell differentiation to osteogenesis through various ways. Therefore， this article reviews the studies on the regulation of multiple stem cells to osteogenic differentiation by lncRNAs. The progress of lncRNAs on differentiation of bone induced by different stem cells， to further explore the function and mechanism of lncRNAs in regulating stem cells， and stem cell therapy provides a more reliable theoretical basis for the treatment and prevention of bone metabolic diseases.
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