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The Role of Mcm10 in Eukaryote Replication Origin
Fu Lingling, Zhao Xiaoyu, Xu Jin*
Department of Preventive Medicine, Medical School of Ningbo University, Ningbo 315211, China
Abstract: DNA replication of the eukaryotic requires precise and rigorous regulation， and it is really important for the initial success of replication initiation， and the assembly of the helicase is the core of the replication initiation. Minichromosome maintenance proteins (Mcms) that act as core components of the helicase and play a major role in the initiation of DNA replication. So far， there have been many studies on Mcm2-7 complex， and there is a comprehensive explanation for its function in the replication initiation. Subsequently， some studies have discovered that Mcm10 is also involved in control of DNA replication origin， but its precise function is not clear. This article gives a brief review about the function of Mcm10 in replication initiation in recent years.
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