Home > Browse Issues > Vol.29 No.6
The Progress in Researches of SRp38 Gene
Zheng-Yu Peng, Wei Zhang1, Xian-Hua Chen, Ping Xu*
State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China; 1Department of Pharmaceutic, City College of Zhejiang University, Hangzhou 310015, China
Abstract: SR proteins play important role in regulating pre-mRNA alternative spicing. As a newly discovered neural and reproductive specific SR protein， SRp38 has typical structure of SR protein and can regulate alternative splicing of several genes such as GLUR-B， TRK-C and NCAML1 etc. But unlike the other SR proteins， during mitosis or stress response， SRp38 can act as splicing inhibitor in order to prevent wrong splicing. The RRM motif of SRp38 can recognize specific mRNAs sequence and the RS domain is responsible for the activity of the modified exon inclusion. The physiological function of SRp38 is regulated by its phosphorylation status. it is dephosphorylated in M phase cells or after heat shock. SRp38 plays important role in neuronal differentiation during early embryogenesis and can also interaction with TLS hint its function as a regulator in neurogenesis as well as carcinogenesis.
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