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The Roles of Leucine Enriched Protein LGI1 in the Occurrence of Epilepsy
Zhou Lin, Shen Ying*
Key Laboratory of Medical Neurobiology of Ministry of Health, Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China
Abstract: Leucine-rich glioma inactivated 1 (LGI1) has a variety of physiological and pathological roles in the central nervous system. LGI1 can regulate the occurrence and development of glioma， modulate the development of cortical lamination and cerebellar foliation， and affect neuronal excitability through ion channels. It also combines transmembrane receptors on neuronal surface to change the release of glutamate neurotransmitter and affects the pathogenesis of epilepsy. However， the mechanisms of LGI1 functions have not been fully understood. In this review， we will introduce recent progresses in the study of LGI1 in epilepsy-related diseases， and discuss plausible therapeutics for these diseases.
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