Home > Browse Issues > Vol.40 No.4
Advances in Anti-Tumor and Anti-Aging Drugs Targeting mTOR
Liu Dan, Peng Lei, Zhang Jihong, Luo Ying*, Liu Jing*
Laboratory of Agronomic and Tumor Molecular Genetics, Medical School, Kunming University of Science and Technology, Kunming 650500, China
Abstract: Mammalian target of rapamycin (mTOR)， a serine/threonine protein kinase， plays important roles in regulating cell growth， proliferation， survival， angiogenesis， protein synthesis and cell cycle. The abnormality of mTOR signaling pathway is closely related to tumor and aging， and has become a target for the treatment of related diseases. This review summarizes the progress of mTOR in the regulation of tumor and senescence ， which is of great significance to the mechanism of tumor and aging-related diseases， and to provide new ideas and methods for the development of anti-tumor and anti-aging therapeutic drugs targeting mTOR signaling pathway.
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