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Progresses in Inhibitory Effect of Non-Drug Treatment on Liver Cells Apoptosis during Hepatic Ischemia-Reperfusion Injury
Wang Peipei1#, Huang Xia1#, Huang Lihuan1, Hong Fenfang2*, Yang Shulong1*
1Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China; 2Department of Experimental Teaching Center, Nanchang University, Nanchang 330031, China
Abstract: Liver is the largest metabolic organ of human body， and its damage may lead to dyshomeostasis. Hepatic ischemia reperfusion injury (HIRI) is a crucial factors of liver dysfunction after liver transplantation for the patients suffered from fatty liver， non-alcoholic cirrhosis and liver cancer. As an autonomous and orderly death model， apoptosis can eliminate the damaged cells from the liver and improve its function. Hence， it is important to maintain the stable state of apoptosis in order to protect the liver from HIRI. Numerous studies have shown that non-drug treatments were helpful to promote apoptosis balance and reduce liver damage during HIRI. Here， this review summarized the progresses in the inhibitory effects of non-drug treatments on liver cells apoptosis during hepatic ischemia reperfusion injury， which involved the apoptosis inducing factors， its signal transduction pathway and its downstream molecules in recent years.
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