Application and Optimizational Strategy for Inducible Lentiviral Vectors

Abstract: As human immunological virus type-1 (HIV-1) based lentiviral vector holds the characteristics of transfection to non-dividing cells， low rate of immunological response， larger capacity of transfer gene fragments and integrating into host genome for long-term expression of therapeutic gene， therefore it becomes one of the idealest gene transfer vectors in gene therapy. Transgene expression could be efficiently controlled by using the inducible lentivectors incorporating regulatable system，which expands the potential of lentivectors for a wide array of clinical gene transfer application， therefore it becomes a potential viral vector in gene therapy. Improvements of tetracycline and other kinds of inducible lentivector， and its application in gene therapy for RNA interference are emphasized in this review.
    

CSTR: 32200.14.cjcb.2007.06.0006