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The Role of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAM) Calcium-Related Proteins in Maintaining Mitochondria Calcium Homeostasis
Gao Peng, Yang Ming, Sun Lin*
Department of Nephrology, Second Xiangya Hospital, Institute of Nephrology, Central South University, Changsha 410011, China
Abstract: The endoplasmic reticulum (ER) and mitochondria are the main storage compartment for cell calcium， which play an important role in calcium homeostasis. The specific sites of physical association between ER and mitochondria are known as mitochondria-associated endoplasmic reticulum membranes (MAM). It has recently become clear that MAMs are crucial for highly efficient transmission of Ca2+ from the ER to mitochondria， thus controlling fundamental processes involved in energy production， determining cell fate and also mitochondria calcium homeostasis. In this review， we summarize the recent progress of the calcium signaling around MAM， emphasizing the mechanism and functions of Ca2+ related proteins of MAM in maintaining mitochondria calcium homeostasis.
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