Home > Browse Issues > Vol.40 No.4
The Aspartate-Mediated Coordination of Cell Proliferation
Liang Yan, Morigen*
State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China
Abstract: Regulation of the cell proliferation and cell growth is complex， which requires a large number of nutrient， energy， cofactor and metabolic intermediates. The paper discussed the roles of aspartate and cell respiration in the cell proliferation. We described the ETC (electron transport chain) working mechanisms and discussed its relationship with cell proliferation. We also summarized the functions of aspartate in the cell cycle progression by reviewing the aspartate metabolism， effects of aspartate in ETC defective cell. The review finds that aspartate accelerates the cell cycle progression through participating in the Krebs cycle and nucleotide metabolism instead of serving as an electron acceptor like pyruvate. The review may provide a clue for further work in regulation of the cell proliferation.
CN
EN