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Progress in Wnt Signal Pathway Antagonists SFRP1 in Cancer
Feng-Yun Zheng, Ji-Cheng Li*
Institute of Cell Biology, Zhejiang University, Hangzhou 310031, China
Abstract: The secreted frizzled related protein 1 (SFRP1) gene， which is located on chromosome 8p11.2， has recently been demonstrated to be a new tumor suppressor gene. Since SFRP1 gene encodes a Wnt signaling antagonist， it causes deregulation of Wnt signaling by inactivation， and finally affects human tumorigenesis and progression. A series of researches about the inactive mechanism of SFRP1 in human malignancies have been done in recent years， and now we review them in this article.
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