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The Progress of Structure Analysis of SMC2/SMC4 Heterodimer of Eukaryotic Condensin
Wang Hongzhen1,2, Yang Sihan1, Li Guiying2*
1School of Life Sciences, Jilin Normal University, Siping 136000, China; 2Key Laboratory for Molecular Enzymology and Engineering of The Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China
Abstract: The main role of eukaryotic condensin is to regulate the chromosome behavior during cell cycle. It is a pentameric protein complex that comprises a core catalytic SMC2/SMC4 heterodimer and three regulatory non-SMC subunits. At present， it is still unclear about the conformation in vivo and molecular mechanism of SMC2/ SMC4 heterodimer of eukaryotic condensin. Recently， many novel progresses have been made in the studies of the structure analysis of SMC2/SMC4 heterodimer. This paper reviewed research progresses of the structure analysis of SMC2/SMC4 heterodimer in recent years in order to provide references to related study on the basis of briefly introduce of primary structure of SMC proteins， the found of eukaryotic condensin and structure and composition of eukaryotic condensin.
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