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Phosphodiesterase Type 3B: Downstream Factor of PI-3K/PKB Pathway as well as Its Clinical Research
Wen Cao, Fang-Xiong Shi*
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Abstract: In the insulin-induced PI-3K/Ak pathway， phosphodiesterase type 3B(PDE3B)， as downstream factor of Akt， plays an important role in the physiological responses such as antiglycogenolysis， antilipolysis， glucose transport by mediating intracellular cAMP level. Recent evidence suggests that variety of PDE3B's activity and expression is one of key factors which lead to insulin resistance. Therefore， PDE3B and some substances affecting activity of PDE3B could be the target to cure Type 2 diabetes and adiposity which pathophysiology are based on insulin resistance.
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