Home > Browse Issues > Vol.40 No.3
The Research Development of Sample Pretreatment in Cell Metabolomics
Xu Jia1,2, Liu Qinan2, Zhai Yuanyuan2, Shan Jinjun1, Yao Weifeng1,2*, Zhang Li2
1Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China; 2Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
Abstract: Cell metabolomics is an important part of systemic biology and a scientific for the overall and dynamic understanding of biological systems. It mainly studies the qualitative and quantitative analyses of small molecular metabolites and observes the changes of metabolites to investigate the metabolic mechanism. Cell metabolomics workflow includes experimental design， sampling， sample processing， metabolite analysis， and data processing. The pretreatment methods of cell metabolomics are not the same， and the design of a reasonable and convenient sample pretreatment method for the late development of metabolomics is essential. We present a brief review of the results of the sample pretreatment at this stage and the method of pretreatment of commonly used cellular metabolomics samples.
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