Home > Browse Issues > Vol.40 No.3
The Progress of Telomere DNA Damage and Cell Senescence
Ying Leqian1, Yu Hui1, Wang Yuting1, Pan Yinan1, Wang Jintao1, Wang Lihui2*
1School of Medicine, Hangzhou Normal University, Hangzhou 310000, China; 2 Institute of Aging Research, Hangzhou Normal University Hangzhou 310000, China
Abstract: Cell senescence is the destiny of the creatures. Various studies have shown that the length of telomere DNA is associated with the ageing process of cells whose telomere DNA probably appear different degrees of damage， such as telomere DNA fragmentation， fusion， shorten and attrition. In consequence， the length of telomere may measure the lifespan， called as the “life clock”. At present， the mechanism of telomere DNA damage and the protection of telomere have been partly clarified. Telomerase， as a reverse transcriptase， maintains telomere length in cells and reduces chromosome damage to ensure the cell division cycle. In this review， we aim to summarize the related mechanism of telomere DNA damage and to clarify the relationship between different types of telomere DNA damages and cell senescence， and to find out the causes of cellular senescence， which consequently will help us to give insights into the transformation of basic research to clinic application and set the theoretical foundation for the development of inhibitors of related cellular senescence channels and the activators of telomerase.
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