Anti-apoptotic and Pro-apoptotic Roles of NF-κB in Cancer

Abstract: Apoptosis plays an important role in both dynamic balance of cells and homeostasis of body. nuclear factors κB (NF-κB) has been shown to be intimately not only involved in the gene regulation such as cell proliferation， differentiation and inflammation， but also participated in the generation， development and metastasis of tumors. Thus， NF-κB has been considered as a target for cancer therapy. The recent works indicate the important role of NF-κB in inflammation-induced cancer， and also approve that activating pro-apoptosis of NF-κB inhibit tumourigenesis. Cognizing the different roles of NF-κB in generation of tumors can provide basic theoretics of cancer therapy.

CSTR: 32200.14.cjcb.2007.06.0003