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Progress in Apoptosis-inducing Factor
Mo Chen, Min-Hui Pan, En-Kun Zhou, Juan Du, Jia Liu, Cheng Lu*
Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, China
Abstract: Apoptosis-inducing factor (AIF) is a conservative flavoprotein which has the difunctionality located in mitochondrial intermembrance space. It catalysises electron transmit between cytochrome c and NAD as mitochondrion oxidoreductase in cell normal physiological state. When death stimuli present， AIF is released from mitochondria to the cytoplasm and then to the nucleus through its nuclear localization sequence (NLS)， inducing peripheral chromatin condensation and large-scale fragmentation of DNA (~50 kb)， the last initiate caspase-independent pathway. The release of AIF is regulated by Bcl-2 proteins and inhibited by Hsp70. Moreover， AIF is a downstream effector in apoptosis pathway mediated by poly (ADP-ribose) polymerase 1 (PARP1).
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