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The Structure and Function of GPC3 and Its Application in the Diagnosis and Treatment of Hepatocellular Carcinoma
Wang Shenghao, Muhammad Kalim, Zhan Jinbiao*
Department of Biochemistry, Zhejiang University School of Medicine, Hangzhou 310058, China
Abstract: Glypican 3 (GPC3) is a phosphatidylinositol-anchored membrane protein， which belongs to the glypican family. GPC3 is highly expressed in hepatocellular carcinoma (HCC) and no present in normal liver cells and benign tumors. Currently， it is mainly used as a biomarker for the diagnosis of primary liver cancer. The HCC patients with high level of GPC3 in the serum and liver tissue tend to have poor prognosis. The study has indicated that GPC3 promotes HCC migration and proliferation by activating Wnt-signaling pathway and other pathways. The monoclonal antibodies， and antibody-drug conjugates and immunotherapy targeting GPC3 provide new weapons for HCC treatment in clinic.
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