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NOX-Mediated Oxidation in the Regulation of Cytoskeleton-Related Activities
Huang Chenkai, Zhang Wang, Gan Dakai, Zhu Xuan*
Department of Digestive Diseases, First Affiliated Hospital, Nanchang University, Nanchang 330006, China
Abstract: Cytoskeleton is the internal support structure for cells to survive， mainly including microtubules， intermediate filaments and microfilaments. Studies have confirmed that the activation of cytoskeleton upstream Rho GTPase， cytoskeleton self-remodeling and cytoskeletal related cell functions such as migration， adhesion and other cell physiological activities are related to intracellular oxidative stress. In recent years， NOX-induced oxidative stress has become one of the important factors affecting cytoskeleton-related activities. This makes it essential for us to understand NOX-induced oxidative stress and cytoskeletal regulation and lay a solid foundation for the study of related diseases.
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