Home > Browse Issues > Vol.40 No.2
Anti-Inflammatory Effect of Prunus tomentosa Thunb Total Flavones on LPS Induced RAW264.7 Cell Inflammation
Liu Yuanyuan1, Zhao Dongshuang1, Zhuang Wenyue2, Chen Xi3, Zhang Chengyi1*
1College of Pharmacy, Beihua University, Jilin 132013, China; 2College of Laboratory Medicine, Beihua University, Jilin 132013, China; 3School of Basic Medicine, Beihua University, Jilin 132013, China
Abstract: This work was aimed to explore the anti-inflammatory mechanism of Prunus tomentosa thunb total flavones (PTTTF) on LPS induced RAW264.7 cell inflammation. By using RAW264.7 cell inflammation model induced by LPS， the effects of PTTTF on the generation of IL-6， IL-1β， and PGE2， and the expressions of COX-1 and COX-2 were examined. The PTTTF at concentration of more than 4 μg/mL significantly inhibited the generation of IL-6， IL-1β and PGE2 (P<0.05); whereas， when PTTTF at concentration of 40 μg/mL， it could inhibit the expression of COX-1， but not that of COX-2. PTTTF can significantly inhibit the generation of cell inflammatory factors IL-6， IL-1β and PGE2， and the expression of COX-2， but have no significant effect on the expression of COX-1.
CN
EN