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Advances of Vascular Neointimal Hyperplasia Regulated by Integrin
Wang Weisen1, Zhang Yi2, Wang Yun2*
1The 3st Battalion of Trainee Brigade, the Third Military Medical University, Chongqing 400038, China; 2Department of Cell Biology, the Third Military Medical University, Chongqing 400038, China
Abstract: Neointimal hyperplasia is a major morphological feature of many cardiovascular diseases such as atherosclerosis and hypertension， it is also responsible for the stenosis of vascular surgery including stent angioplasty and arteriovenous fistula surgery. Integrin-mediated cell adhesion plays a very important role in neointimal hyperplasia development. We reveiwed here the effect of integrin on neointimal formation through regulating leucocyte adhesion， smooth muscle cell proliferation and migration， reendothelialization as well as the frequently used animal model of neointimal hyperplasia. Understanding the mechanisms of neointimal hyperplasia modulated by integrin will provide new therapeutic strategies for these clinical diseases.
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