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The Regulatory Role of Phosphatidylinositol Signaling in GLUT4 Vesicle Trafficking
Xiao Mei1, Zhao Xuqin1, Xu Yingke2, Li Hanbing1*
1Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; 2Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou 310027, China
Abstract: Glucose transporter 4 (GLUT4) is essential for the uptake of glucose into insulin-sensitive adipocytes and muscle cells and for its intracellular metabolism. Phosphatidylinositol， which works as localization signal of various proteins， plays an important role in regulation of cell growth， metabolism and insulin signaling transduction. Over the last few decades， much progress has been made on studying of the role of phosphatidylinositol signaling and GLUT4 translocation. This review summarizes the latest research on the regulatory role of phosphatidylinositol in intracellular GLUT4 vesicle trafficking.
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