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The Biological Function of Inositol Hexaphosphate Kinases (IP6Ks) and It’s Role in the Development of Diseases
Wang Yongrong, Liu Fei, Xu Yuanfu*
State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
Abstract: Both soluble and lipid states of inositol phosphates exist extensively in eukaryotic cells and play important roles in cell development and biological processes. Among them， inositol hexaphosphate kinases (IP6Ks)， the key rate-limiting enzymes in the synthesis of inositol pyrophosphates， can biologically add a phosphate group in the first/third/fifth site of inositol ring to synthesize inositol pyrophosphate， such as 5-pyrophosphate inositol pentaphosphate (IP7， PP-IP5) and bis-diphosphoinositol tetrakisphosphate (IP8， [PP]2-IP4). As to function， IP6Ks can pose effect on DNA repairing， chromosome recombination， cell death， coagulation， hematopoietic regulation， immunoregulation， cancer progression， etc. Therefore， more and more attention have been taken into the diverse roles of IP6Ks. Based on the previous experimental studies， the functions of IP6Ks in cellular processes are reviewed in this paper.
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