New Insights into the Role of Endoplasmic Reticulum Stress Signaling Protein XBP1 in Tumor Progression

Abstract: X-box binding protein 1 (XBP1) was the main regulatory factor in endoplasmic reticulum stress. XBP1 was highly expressed in different kinds of malignant tumors. Many research findings revealed that XBP1 could promote tumor cells to survive in the condition of hypoxia and induce drug resistance. Recent studies demonstrated that XBP1 could induce angiogenesis in malignant tumors by a varies of mechanisms. And moreover， XBP1 can inhibit the host anti-tumor immunity， and facilitate the immune escape of malignant tumor cells， which thereby leading to rapid proliferation and accelerating the invasion and metastasis of malignant tumors. Therefore， it was postulated that XBP1 inhibition could represent a significant approach to increase the efficacy of cancer treatment， especially in various forms of cancer immunotherapy.

CSTR: 32200.14.cjcb.2017.12.0016