Home > Browse Issues > Vol.39 No.12
The Autophagy in Picornavirus Infection
Zhou Shan, Cheng Anchun*, Wang Mingshu*
Avian Disease Research Center, College of Veterinary Medicine, Key Laboratory of Animal Disease and Human Health of Sichuan Province, Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Abstract: Autophagy， a highly conserved lysosomal pathway in eukaryotic cells， is responsible for the degradation of intracellular misfolded or redundant proteins， damaged organelles and intracellular pathogens. The picornaviruses uncoating infection rapidly induces autophagy， which further activates the formation of substantial autophogosomes. Autophagy， as an innate antiviral immune pathway， can promote cell surface pattern recognition receptors and interferon pathway， and enhances presentation effect of major histocompatibility complex on virus antigens to inhibit picornavirus infection and replication. In addition， given that autophogosome provides picornavirus replication protease and autophagosome-mediated exit without lysis， autophagy can enhance intracellular and extracellular virus production via promoting picornavirus genome duplication and progeny virion release. This review concludes the role of autophagy on picornavirus replication， in order to support certain basis for analyzing the relationship between the infection of different picornavirus and the time and space of autophagy， and illustrating molecular mechanism of autophagy in picornavirus infection.
CN
EN