The Progresses on the Prostate Apoptosis Response Protein-4 Inducing Apoptosis Selectively in Cancer Cells and Its Mechanism

Abstract: In tumor therapy， looking for a drug that hastheselectively effect on tumor cellsis people expected. As a tumor suppressor the prostate apoptosis response protein-4 (Par-4) can selectively induce apoptosis of the tumor cells and play a role in both cytoplasm and nucleus. However， it be found that par-4 can be secreted and interact with the GRP78 onthe cell surface， causing the endoplasmic reticulum stress， which activates the FADD/caspase-8/caspase-3 pathway leading to apoptosis. Par-4 interacts with other proteins and anticancer drugs during the exercise of its function， and they can co-induce tumor cells apoptosis， which provides new methods and ideas for tumor therapy. This paper reviews the regulatory mechanisms of Par-4 on the selective induction of tumor cell apoptosis and its interaction with relevant genes and other antitumor agents.

CSTR: 32200.14.cjcb.2017.12.0013