Home > Browse Issues > Vol.39 No.11
Advances on TORC1 Pathway Upstream Regular Elements and Ribosome Biosynthesis Function in Saccharomyces cerevisiae
Zhang Wenzhe2, Li Wanjie1,2*
1Key Lab of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing 100875, China; 2College of Life Science, Beijing Normal University, Beijing 100875, China
Abstract: TORC1 (target of rapamycin complex 1) is composed from Kog1， Lst8， Tco89 and either Tor1 or Tor2 in Saccharomyces cerevisiae. As the target of rapamycin， Tor1 and Tor2 were discovered in 1991. Some recent researches show that TORC1 and another similar complex， TORC2， play roles in many cell processes， such as nutrition metabolism， ribosome biosynthesis， cell cycle， autophagy， aging and etc. Recent discoveries in EGO complex， which is an important upstream element of TORC1， interprete how TORC1 sensed surrounding amino acid to a large extent if not all. Ribosome biosynthesis is a highly energy-consumed process， while TORC1 plays an important role in controlling synthesis of rRNA and ribosomal proteins (RP). This review not only looked back on the discovery of TORC1 in S. cerevisiae， but also summarized recent research on TORC1 upstream regular elements
and its roles in ribosome biosynthesis.
and its roles in ribosome biosynthesis.
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