Home > Browse Issues > Vol.39 No.11
Progress on Epigenetic Drugs in Development of Somatic Cell Nuclear Transfer Embryos
Ma Panpan, Yang Shubao, Luan Weimin*, Ma Xin*
College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China
Abstract: Somatic cell nuclear transfer (SCNT) is a technology， which makes reprogramming of highly differentiated somatic cell nuclear by making use of cytoplasmic reprogramming material in the oocyte， finally restores the totipotency and develops into a new number. In SCNT， epigenetic modifications participate in reprogramming of oocyte， such as modifications of DNA methylation patterns and histone modification after translation， their abnormal expression has adverse impacts on the development of SCNT embryos. Epigenetic drugs， such as DNA methyltransferase inhibitors and histone deacetylase inhibitors， can improve the abnormal epigenetic modifications and promote the reprogramming of SCNT embryos. This paper summarizes the abnormal epigenetic modifications in the process of SCNT embryonic development as well as the progress of epigenetic drugs. The effects of the drugs on SCNT embryos development were discussed further.
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