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The Role of VEGF and EGFL in Bone Angiogenesis
Tong Xiaoyang1, Li Hui1, Zhang Miao1, Chen Xi1,2, Zou Jun3*
1School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China; 2School of Sports Science, Wenzhou Medical University, Wenzhou 325035, China; 3Development and Planning Office, Shanghai University of Sport, Shanghai 200438, China
Abstract: Bone is a highly vascularized tissue containing an extensive vascular network of large vessels and capillaries， which provide oxygen and nutrients for bone formation and development through regulation of different signaling pathways between bone cells and endothelial cells. Numbers of studies have proved that the variation of vasculature are closely related to the development of many bone diseases. Many factors play essential roles in the regulation of bone angiogenesis. This study mainly reviewed the functions of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF)-like family members (EGFL) in the regulation of bone angiogenesis， providing more understanding of the treatment of relevant bone diseases.
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