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The Study of Serum MicroRNA 32-3p as Potential Noninvasive Biomarker in the Diagnosis of Acute Ischemic Stroke
Han Bing1#, Yao Yuan1,2#, Guo Xiaoliang1, Li Pan1, Yuan Jun1, Zhu Runxiu1*
1Department of Neurology of Inner Mongolia People′s Hospital, Hohhot 010017, China; 2School of Life Sciences, Inner Mongolia University, Hohhot 010021, China
Abstract: This work was aim to explore the association and role of serum miR-32-3p in patients with acute ischemic stroke (AIS). Blood samples were obtained from AIS patients (n=89) and controls (healthy， n=89). miR- 32-3p was measured by RT-qPCR. Bioinformatics database assay was used to predict comprehensively target genes， and the gene ontology and enriched pathway of target genes were analyzed by DAVID database. The results showed that the serum miR-32-3p level was significantly increased about 3.28 times in stroke patients compared with the controls (P<0.001). The miR-32-3p was associated with the cerebral ischemia， reperfusion injury and apoptosis after cerebral ischemia. The results suggested that the miR-32-3p level was significantly increased in serum of patients， and serum miR-32-3p might be a novel potential biomarker for clinical diagnosis of AIS.
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