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Signal Pathway and Regulation of Ferroptosis
Jin Weiwei, Jing Shenrong*
Laboratory of Genetic Gngineering Pharmaceutical, Medical School, Kunming University of Science and Technology, Kunming 650500, China
Abstract: Ferroptosis， found in recent years， is a kind of regulation of cell death. There are significant differences in biochemistry， gene and morphology from other forms of cell death. The Ferroptosis process is controlled by strict and complex regulatory mechanisms， characterized by lipid peroxidation and lethal reactive oxygen species (ROS) accumulation. And the Ferroptosis process can be inhibited by iron chelators and lipid peroxidation inhibitors. The regulation of Ferroptosis is associated with a variety of physiological and pathological processes， including the death of tumor cells， neurodegenerative diseases， acute renal failure and liver and heart ischemia reperfusion injury.
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