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Regulation of Forkhead Box C Genes on Craniomaxillofacial Bone Tissue Development
Si Jiawen1, Steve G.F. Shen1*, Guo Lihe2*
1Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; 2Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: The forkhead box C (Foxc) genes are highly conserved in various species such as humans and rodents. The subfamily members of Foxc genes， namely Foxc1 and Foxc2， which have been proven to be participated in several important signal transduction pathways， and are closely related to the development and function of the human neural， skeletal and circulatory system. Recent studies have suggested that Foxc1 and Foxc2 may play an important and cooperative role in regulation of the development of the craniomaxillofacial bone tissue and teeth. In this paper， the research progress of the regulation of Foxc genes on craniomaxillofacial bone tissue development is reviewed.
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