Home > Browse Issues > Vol.39 No.9
Progress of Polysaccharides Regulating p53 Signal Network
Zhen Dong1, Zhao Fei1, Song Hui1,2*
1School of Life Science, Jilin Agriculture University, Changchun 130118, China;2Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Changchun 130118, China
Abstract: p53 is one of the most extensive and systematic cancer suppressor genes and its function-related genes consists of a complicated gene network. The mutation and deletion of the p53 gene is highly associated with the development of human malignancies， so p53 gene is a target for the developments of the anti-cancer drugs. Polysaccharides are attracted more attention on antitumor drug screening with having low side effects. The polysaccharides are enhancing the immunity and regulated the intracellular signaling pathways to achieve its antitumor activity. We summarized the research advance of antitumor mechanism of polysaccharides through the regulation of p53 signal network， which provided some basis for the development and utilization of polysaccharides for the future studies.
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