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The Mechanism of Intergrin Internalization and Recycling
Zhang Luxin, Zhang Xin, Wang Jihong*
College of Life Sciences, Liaoning Normal University, Dalian 10165, China
Abstract: Integrins are heterodimeric transmembrane receptors implicated in cell proliferation， migration， differentiation and apotosis by mediating the interaction of cells with cells， extracellular matrix (ECM) and pathogens， and play an important role in the progression of diseases like cancer. The ablility of integrin binding with ligands depends on its conformation and activity， which plays a key role in the regulation of integrin function. Many studies have found that certain intergrin heterodimers are continuously internalized from the plasma membrane into endosomal compartments and subsequently recycled back to the cell surface. This process is mainly through fast (short-loop) and slow (long-loop) pathways to complete recycle. It indicates a tempo-spatial regulation for the integrin internalization and recycling pathways. This review elucidates the molecular mechanisms and recycling pathways of integrin internalization.
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