The Roles of Estrogen Receptor in Thyroid Cancer

Abstract: Estrogen receptor (ER) is the members of the nulear receptor superfamily. It plays an important role in its biological functions through inducing the transcription of its target genes in a ligand-dependent manner. In the process， ER recruits a series of co-regulators to be involved in regulation of gene transcription mediated by ER. ER plays a crucial role in the promotion of the maturity of sexual organ， the development of secondary sexual characteristics and maintenance of sexual function. On the other hand， ER plays an important role in the tumorigenesis and the development of a number of cancers which are connected with esteogen hormone receptors. Tumorigenesis of thyroid cancer is more prevalent in female than that in male， and thyroid cancer is a kind of tumor with sexual tendnecy. It has been reported that thyroid cancer is related to the function of sexual hormone receptors. The researches have proved that the co-regulators of ER also play an important roles in ER-related cancer by participating in the modulation of its target gene transcription. In addition， a variety of environmental stimuli and the cell activity are also involved in the regulation of ER for tumor control. Here， we would review the effect and the machanism of estrogen receptor in thyroid cancer. All in all， we would try to provide some new ideas and novel targets for the treatment and prevention in the thyroid cancer.

CSTR: 32200.14.cjcb.2017.09.0012