Home > Browse Issues > Vol.39 No.9
Mechanisms Underlying Apoptosis Process in Liver Aging
Zhong Huahua1, Hu Shaojie1, Yu Bo1, Jiang Shasha1, Zhang Jin1, Luo Dan1, Hong Fenfang2, Yang Shulong1*
1Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China; 2Department of Experimental Teaching Center, Nanchang University, Nanchang 330031, China
Abstract: Liver is the metabolic organ of the human body， which renders it particularly significant in the body aging. Fatty liver， liver cirrhosis， liver cancer as well as other senile liver diseases are closely related to liver aging. More and more research evidences suggest that apoptosis， as a self-eliminating mechanism， play a vital role in liver aging. Maintaining apoptosis to a certain extent is essential for liver aging: excessive apoptosis of liver cell leads to liverdisfunction， liver diseases aggravation and ultimately liver failure; whereas apoptosis incapacity of liver cell may cause the accumulation of damaged cells and lead to its necrosis or hepatocarcinoma. Therefore， only to maintain a delicate balance of liver cell apoptosis during liver aging， the maximum senescence delay or the minimum impact of aging on the body can be achieved. Here we select several current research focuses， namely， oxidative stress， genomic instability， lipotoxicity， endoplasmic reticulum stress and nutrient sensing dysregulation to elaborate the mechanisms underline apoptosis in liver aging.
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